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· K. Touhara*, K., D. Rossen, D., Deng, F., Castro, J., M. Harrington. A., Chu, T., Garcia-Caraballo, S., Brizuela, M., O'Donnell, T., Xu, J., Cil, O., M. Brierley, S.*, Li, Y.* & Julius, D.* (2025) Topological segregation of stress sensors along the gut crypt-villus axis. Nature. [Full Text] [PDF]

· Xia, X., & Li, Y.* (2025) A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release. Nature Communications. [Full Text] [PDF] [Supplemental Data]
[Nature Communications | 新技术-新发现-新想法：李毓龙团队揭秘神经肽-小分子神经递质共同传递在体内的动态差异和调控机制]

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· Yang J.#, Zhao, T.#, Fan, J.#, Zou, H.#, Lan, G., Guo, F., Shi, Y., Ke, H., Yu, H., Yue, Z., Wang, X., Bai Y., Li, S., Liu, Y., Wang, X., Chen, Y.*, Li, Y.*, & Lei, X.* (2024) Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell. Volume 187, Issue 25. [Full Text] [PDF] [Supplemental Data]
[Cell | 李毓龙与合作者阐明胆汁淤积瘙痒分子机制，开辟肝病治疗新途径]

· Lv, M., Cai, R., Zhang, R., Xia, X., Li, X., Wang, Y., Wang, H., Zeng, J., Xue, Y., Mao, L., & Li, Y.* (2024). An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning. National Science Review. 11(5): nwae112. [Full Text] [PDF] [Supplemental Data]
[NSR | 李毓龙实验室开发新型探针解析章鱼胺在果蝇厌恶性学习中的时空动态变化及其扮演的重要角色]

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· Umpierre, A. D.#*, Li, B.#, Ayasoufi, K., Simon, W. L., Zhao, S., Xie, M., Thyen, G., Hur, B., Zheng, J., Liang, Y., Bosco, D. B., Maynes, M. A., Wu, Z., Yu, X., Sung, J., Johnson, A. J., Li, Y.*, & Wu, L.-J.* (2024) Microglial P2Y₆ calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron. 112(12): 1959-1977. e10. [Full Text] [PDF] [Supplemental Data] [UDP Release Dynamics ex vivo] [UDP Release Dynamics in vivo]
[Neuron︱梅奥医学中心伍龙军/北京大学李毓龙团队揭示UDP-P2Y6-钙信号通路促进小胶质细胞吞噬能力和神经免疫反应]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.06.12.544691v1

· Feng, J.*, Dong, H., Lischinsky, J. E., Zhou, J., Deng, F., Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., Xie, H., Cui, G., Lin, D., & Li, Y.* (2024). Monitoring norepinephrine release in vivo using next-generation GRABNE sensors. Neuron. 112(12): 1930-1942. e6. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙实验室新升级第二代去甲肾上腺素探针助力活体神经递质研究]

See also BioRxiv https://doi.org/10.1101/2023.06.22.546075

· Deng, F.#, Wan, J.#, Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y., Liu, L., Yan, Y., Feng, J., Zhao, Y., Xie, H., & Li, Y.*(2024). Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo. Nature Methods. 21(4): 692-702. [Full Text] [PDF] [Supplemental Data] [5-HT and Ca2+ Waves During Seizure] [5-HT and eCB Waves During Seizure]
[Nature Methods | 李毓龙实验室升级五羟色胺探针实现超高灵敏度的双色成像]

See also BioRxiv https://www.biorxiv.org/content/biorxiv/early/2023/05/30/2023.05.27.542566.full.pdf

· Zhuo, Y.#, Luo, B.#, Yi, X., Dong, H., Miao, X., Wan, J., Williams, J. T., Campbell, M. G., Cai, R., Qian, T., Li, F., Weber, S. J., Wang, L., Li, B., Wei, Y., Li, G., Wang, H., Zheng, Y., Zhao, Y., Wolf, M. E., Zhu, Y., Watabe-Uchida, M., & Li, Y.* (2024). Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods. 21(4): 680-691. [Full Text] [PDF] [Supplemental Data]
[Nature Methods | 李毓龙实验室新升级第三代红绿多巴胺探针工具包上线]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.08.24.554559v1

· Wang, H.#, Qian, T.#, Zhao, Y., Zhuo, Y., Wu, C., Osakada, T., Chen, P., Chen, Z., Ren, H., Yan, Y., Geng, L., Fu, S., Mei, L., Li, G., Wu, L., Jiang, Y., Qian, W., Zhang, L., Peng, W., Xu, M., Hu, J., Jiang, M., Chen, L., Tang, C., Zhu, Y., Lin, D., Zhou, J.-N., & Li, Y.* (2023). A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors. Science , 382(6672), eabq8173. [Full Text] [PDF] [Supplemental Data] [Distinct SST Spatial Signal Patterns]
[Science | 移花接木——李毓龙实验室设计通用型嫁接策略开发神经肽探针工具包]

See also BioRxiv https://doi.org/10.1101/2022.03.26.485911

· Wu, Z.#, Cui, Y.#, Wang, H.#, Wu, H., Wan, Y., Li, B., Wang, L., Pan, S., Peng, W., Dong, A., Yuan, Z., Jing, M., Xu, M., Luo, M.*, & Li, Y.* (2023). Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor. Proceedings of the National Academy of Sciences, 120(14), e2212387120. [Full Text] [PDF] [Supplemental Data]
[PNAS | 新技术-新发现-新想法：李毓龙团队与合作者揭示“神经调质”腺苷的释放及调控机制]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.05.04.075564

· Dong, H.#, Li, M.#, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R., & Li, Y.* (2023). Genetically encoded sensors for measuring histamine release both in vitro and in vivo. Neuron. 111(10): 1564-1576. e6. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙团队利用新型GRAB探针，解析组胺在睡眠-觉醒过程中的动态变化]

See also BioRxiv https://doi.org/10.1101/2022.08.19.504485

· Zeng, J.#*, Li, X.#, Zhang, R., Lv, M., Wang, Y., Tan, K., Xia, X., Wan, J., Jing, M., Zhang, X., Li, Y., Yang, Y., Wang, L., Chu, J., Li, Y., & Li, Y.*. (2023). Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning. Neuron. 111(7): 1118-1135. e5. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙团队发现五羟色胺调节关联学习记忆的时间窗口，揭开巴甫洛夫留下的百年之谜]

See also BioRxiv https://doi.org/10.1101/2022.03.27.485970

· Qian, T.#, Wang, H.#, Wang, P.#, Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., & Li, Y.* (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments. Nature Biotechnology. 41(7): 944-957. [Full Text] [PDF] [Supplemental Data] [OT Signals in the VTA During Mating] [OT Signals in the PVN During Mating] [OT Signals in the PFC During Mating]
[Nature Biotechnology | 李毓龙实验室开发新型催产素荧光探针，揭秘神经肽的时空动态调控]

See also BioRxiv https://doi.org/10.1101/2022.02.10.480016

· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Wang, H., Du, J., Jing, M., & Li, Y.* (2021). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo Neuron, 110(5), 770-782.e775. [Full Text] [PDF] [Supplemental Data]

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[Neuron | 李毓龙实验室开发新型GRAB荧光探针用于检测胞外ATP的时空动态变化]
入选"Best of Neuron 2021-2022"

See also BioRxiv https://doi.org/10.1101/2021.02.24.432680

· Dong, A., He, K., Dudok, B., Farrell, J. S., Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Wang, H., Duan, J., Albarran, E., Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y.*. (2021). A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo. Nature Biotechnology. 40(5): 787-798. [Full Text] [PDF] [Supplemental Data] [eCB and Ca2+ Signals During Seizures]
[Nature Biotechnology | 李毓龙实验室开发新型荧光探针用于检测内源大麻素的时空动态变化]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.10.08.329169

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[eLife | 李毓龙实验室发现定位于突触小泡的新型转运体]

See also BioRxiv https://doi.org/10.1101/2020.12.01.405605

· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*. (2021). A genetically encoded sensor for measuring serotonin dynamics. Nature Neuroscience. 24(5): 746-752. https://doi.org/10.1038/s41593-021-00823-7. [Full Text] [PDF] [Supplemental Data] [5-HT Release in Drosophila]
[Nature Neuroscience | 李毓龙实验室开发新型荧光探针实现在体5-羟色胺动态变化的精确检测]

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[Nature Methods | 李毓龙实验室合作实现新型红色荧光多巴胺探针和第二代绿色荧光多巴胺探针的开发及应用]

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[Nature Methods | 新一代乙酰胆碱探针实现体内乙酰胆碱信号的精确解析]

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[eLife | 李毓龙研究组与合作者报道胆汁淤积瘙痒的分子机制]

· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF] [Supplemental Data] [Video Abstract]
[Neuron | 李毓龙研究组报道新型基因编码的去甲肾上腺素荧光探针]

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[eLife | 李毓龙研究组开发检测缝隙连接的新型光遗传学方法]

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[央视报道 | 北大生科李毓龙研究组发明新型多巴胺“探针”]

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[NBT | 北大李毓龙组开发新型乙酰胆碱荧光探针——专家点评]

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