English   李毓龙实验室
[新!]材料与资源
首页
研究员
实验室成员
研究方向
部分发表论文
招聘
实验室活动
如何抵达
 

部分发表论文

[预印本 |主要研究论文 |合作发表论文 |综述,书评等 ]

预印本

·Dong, A.,He, K., Dudok, B., Farrell, J. S., Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Duan, J., Albarran, E., Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y. (2020). A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo. bioRxiv, https://doi.org/10.1101/2020.10.08.329169. [Full Text] [PDF]

·Gallo, E. F.*, Greenwald, J., Teboul, E., Martyniuk, K. M., Li, Y. , Javitch, J. A., Balsam, P. D. & Kellendonk C.* (2020). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. bioRxiv, https://doi.org/10.1101/2020.09.07.284612. [Full Text] [PDF]

·Kjaerby, C.#, Andersen, M.#, Hauglund, N., Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, K. P., Feng, J., Li, Y. , Weikop, P., Hirase, H.& Nedergaard, M.* (2020). Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions. bioRxiv, https://doi.org/10.1101/2020.09.01.274977. [Full Text] [PDF]

·Hamilos, A. E., Spedicato, G. Hong, Y., Sun, F., Li, Y. & Assad, J. A.* (2020). Dynamic dopaminergic activity controls the timing of self-timed movement. bioRxiv, 1420-19. [Full Text] [PDF]

·Wu, Z., Cui, Y., Wang, H., Song, K., Yuan, Z., Dong, A., Wu, H., Wan, Y., Pan, S., Peng, W., Jing, M., Xu, M., Luo, M. & Li, Y. * (2020). A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release. bioRxiv, https://doi.org/10.1101/2020.05.04.075564. [Full Text] [PDF]

·Sethuramanujam, S., Matsumoto, A., McIntosh, J. M., Jing, M., Li, Y. , Berson, D., Yonehara, K.*, & Awatramani, G. B. * (2020). Rapid ‘multi-directed’ cholinergic transmission at central synapses. bioRxiv, https://doi.org/10.1101/2020.04.18.048330. [Full Text] [PDF]

· Sturgill, J. F., Hegedus, P., Li, S. J., Chevy, Q, Siebels, A., Jing, M., Li, Y., Hangya, B.* & Kepecs, A.*(2020). Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error. bioRxiv, https://doi.org/10.1101/2020.02.17.953141. [Full Text] [PDF]

· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.(2019). A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo. bioRxiv, https://doi.org/10.1101/2020.02.24.962282. [Full Text] [PDF]

主要研究论文

· Mayer, F. P., Iwamoto, H., Hahn, M. K., Grumbar, G. J., Stewart, A., Li, Y., & Blakely, R. D. (2021). There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens. Neurochemistry International, 142, 104894. https://doi.org/https://doi.org/10.1016/j.neuint.2020.104894 [Full Text] [PDF]

· Kim, H. R.#*, Malik, A. N., Mikhael, J. G., Bech, P., Tsutsui-Kimura, I., Sun, F., Zhang, Y., &Li, Y., Watabe-Uchida, M., Gershman, S. J., & Uchida, N.* (2020). A Unified Framework for Dopamine Signals across Timescales. Cell, https://doi.org/https://doi.org/10.1016/j.cell.2020.11.013 [Full Text] [PDF]

· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020). Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods, https://doi.org/10.1038/s41592-020-00981-9. [Full Text] [PDF]

· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Wu, R., Zhang, S., Pan, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, https://doi.org/10.1038/s41592-020-0953-2. [Full Text] [PDF]

· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*. (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431. [Full Text] [PDF]

· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF]

· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics. [Full Text] [PDF]

· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366. [Full Text] [PDF]

* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS. eLife, 8, e45207. [Full Text][PDF]

· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496. [Full Text] [PDF][Suppl Video 1][Suppl Video 2]

* See Viewpoint by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New optical probes bring dopamine to light. Biochemistry, 6379-6381. [Full Text][PDF]

· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737. [Full Text] [PDF][Suppl Figs][Suppl Videos]

* See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648. [Full Text][PDF]

·Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053. [Full Text] [PDF]

· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187. [Full Text] [PDF]

合作发表论文

·Crouse,R. B., Kim, K., Batchelor, H. M., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D A., Jing, M. , Li, Y., Gao, X., Mineur , Y. S., & Picciotto, M. R. * (2020). Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. eLife, 9:e57335. [Full Text] [PDF]

· Kwak, H., Koh, W., Kim, S., Song, K., Shin, J., Lee, J. M., Lee, E. H., Bae, J. Y., Ha, G. E., Oh, J. Park, Y. M., Kim, S., Feng, J., Lee, S. E., Choi, J. W., Kim, K. H., Kim, Y. S., Woo, J., Lee, D., Son, T., Kwon, S. W., Park, K. D., Yoon, B. Lee, J., Li, Y. , Lee, H., Bae, Y. C., Lee, C. J.* & Cheong, E.* (2020). Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron, https://doi.org/10.1016/j.neuron.2020.08.013. [Full Text] [PDF]

·Peng, W.#, Wu, Z.#, Kun, S.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208. [Full Text] [PDF]

·Mazzone, C.M., Liang-Guallpa, J.,Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. A., Reddy, D. M., Sun, F., Zhang, Y., Li, Y., Cui, G. * & Krashes, M. J.* (2020). High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nature Neuroscience, https://doi.org/10.1038/s41593-020-0684-9. [Full Text] [PDF]

·DeGroot, S.R., Zhao-Shea, R., Chung L., Klenowski, P.M., Sun, F., Molas, S., Gardner, P.D., Li, Y. & Tapper, A.R.* (2020). Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2020.06.018. [Full Text] [PDF]

·Zhu, P. K. ,Zheng, W. S. , Zhang, P., Jing, M., Borden, P. M., Ali, F., Guo, K., Feng, J., Marvin, J. S., Wang, Y., Wan, J., Gan, L., Kwan, A. C., Lin, L., Looger, L. L., Li, Y. & Zhang, Y.* (2020). Nanoscopic visualization of restricted nonvolume cholinergic and monoaminergic transmission with genetically encoded sensors. Nano Lett., https://doi.org/10.1021/acs.nanolett.9b04877. [Full Text] [PDF]

· Lin, R.*, Liang, J., Wang, R., Yan, T., Zhou, Y., Liu, Y., Feng, Q., Sun, F., Li, Y., Li, A., Gong, H., & Luo, M.* (2020). The raphe dopamine system controls the expression of incentive memory. Neuron, 1420-19. [Full Text] [PDF]

· Zhang, X., Noyes, N. C. , Zeng, J., Li, Y. & Davis, R. L.* (2019). Aversive training induces both pre- and postsynaptic suppression in Drosophila. The Journal of Neuroscience, 1420-19. [Full Text] [PDF]

· Handler, A., Graham, T. G. M., Cohn, R., Morantte, I., Siliciano, A. F., Zeng J., Li, Y. & Ruta, V.* (2019). Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning. Cell, 178(1), 60-75. [Full Text] [PDF]

· Liang, X., Ho, M. C., Zhang, Y., Li, Y., Wu, M. N., Holy, T. E., & Taghert, P. H.*  (2019). Morning and evening circadian pacemakers independently drive premotor centers via a specific dopamine relay. Neuron, 102(4), 843-857. [Full Text] [PDF]

· Zhou, M.#, Chen, N.#, Tian, J., Zeng, J., Zhang, Y., Zhang, X., Guo, J., Sun, J., Li, Y., Guo, A.*, & Li, Y.* (2019). Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning. Proceedings of the National Academy of Sciences, 201812342. [Full Text] [PDF]

· Li, B.#, Wong, C.#, Gao, S. M., Zhang, R., Sun, R., Li, Y., & *Song, Y. (2018). The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. eLife, 7, e38181. [Full Text] [PDF]

· Tanaka, M., Sun, F., Li, Y., & Mooney, R.* (2018). A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. Nature, 563(7729), 117-120. [Full Text] [PDF][Extended data][Supplementary information]

· Chen, B.#, Huang, X.#, Gou, D., Zeng, J., Chen , G., Pang, M., Hu, Y., Zhao, Z., Wu, H., Cheng, H., Zhang, Z., Xu, C., & Li, Y., Chen, L.*, Wang, A.* (2018). Rapid volumetric imaging with Bessel-Beam three-photon microscopy. Biomedical optics express, 9(4), 1992-2000. [Full Text] [PDF]

· Shen, Y., Ge, W. P., Li, Y., Hirano, A., Lee, H. Y., Rohlmann, A., Missler, M., Tsien, R. W., Jan, L. Y., Fu, Y. H.* & Ptacek, L. J.* (2015). Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences, 112(10), 2935-2941. [Full Text] [PDF]

· Liang, L., Li, Y., Potter, C. J., Yizhar, O., Deisseroth, K., Tsien, R. W., & Luo, L.* (2013). GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron, 79(5), 917-931. [Full Text] [PDF]

· Park, H., Li, Y., & Tsien, R. W.* (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science, 335(6074), 1362-1366. [Full Text] [PDF]

· Yoo, A. S.*, Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien R. W. & Crabtree, G. R.* (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature, 476(7359), 228-231. [Full Text] [PDF]

· Zhang, Q., Li, Y., & Tsien, R. W.* (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science, 323(5920), 1448-1453. [Full Text] [PDF]

· Kuner, T.*, Li, Y., Gee, K. R., Bonewald, L. F., & Augustine, G. J. (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proceedings of the National Academy of Sciences, 105(1), 347-352. [Full Text] [PDF]

综述,书评等

· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese) [Full Text] [PDF]

· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008. [Full Text] [PDF]

· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010. [Full Text] [PDF]

· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]

· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap junctions in the nervous system: probing functional connections using new imaging approaches. Frontiers in Cellular Neuroscience, 12, 320. [Full Text] [PDF]

· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. [Full Text] [PDF]

· Wang, A.#, Feng, J.#, Li, Y.*, & Zou, P.* (2018). Beyond fluorescent proteins: hybrid and bioluminescent indicators for imaging neural activities. ACS chemical neuroscience, 9(4), 639-650. [Full Text] [PDF]

· Qian, C., & Li, Y.* (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929. [Full Text] [PDF]

· Li, Y.*, & Rao, Y.* (2015). Pied piper of neuroscience. Cell, 163(2), 267-268. [Full Text] [PDF]