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·Gallo, E. F.*, Greenwald, J., Teboul, E., Martyniuk, K. M., Li, Y. , Javitch, J. A., Balsam, P. D. & Kellendonk C.* (2020). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. bioRxiv, https://doi.org/10.1101/2020.09.07.284612. [Full Text] [PDF]

·Kjaerby, C.#, Andersen, M.#, Hauglund, N., Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, K. P., Feng, J., Li, Y. , Weikop, P., Hirase, H.& Nedergaard, M.* (2020). Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions. bioRxiv, https://doi.org/10.1101/2020.09.01.274977. [Full Text] [PDF]

·Hamilos, A. E., Spedicato, G. Hong, Y., Sun, F., Li, Y. & Assad, J. A.* (2020). Dynamic dopaminergic activity controls the timing of self-timed movement. bioRxiv, 1420-19. [Full Text] [PDF]

·Wu, Z., Cui, Y., Wang, H., Song, K., Yuan, Z., Dong, A., Wu, H., Wan, Y., Pan, S., Peng, W., Jing, M., Xu, M., Luo, M. & Li, Y. * (2020). A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release. bioRxiv, https://doi.org/10.1101/2020.05.04.075564. [Full Text] [PDF]

·Sethuramanujam, S., Matsumoto, A., McIntosh, J. M., Jing, M., Li, Y. , Berson, D., Yonehara, K.*, & Awatramani, G. B. * (2020). Rapid ‘multi-directed’ cholinergic transmission at central synapses. bioRxiv, https://doi.org/10.1101/2020.04.18.048330. [Full Text] [PDF]

·Crouse,R. B., Kim, K., Batchelor, H. M., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D A., Jing, M. , Li, Y., Gao, X., Mineur , Y. S., & Picciotto, M. R. * (2020). Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. bioRxiv, https://doi.org/10.1101/2020.04.14.041152. [Full Text] [PDF]

· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Tan, K.,Feng, J., Dong, H., Qian, C., Lin, D.*, Cui, G.*, & Li, Y.*(2020). New and improved GRAB fluorescent sensors for monitoring dopaminergic activity in vivo. bioRxiv, https://doi.org/10.1101/2020.03.28.013722. [Full Text] [PDF]

· Sturgill, J. F., Hegedus, P., Li, S. J., Chevy, Q, Siebels, A., Jing, M., Li, Y., Hangya, B.* & Kepecs, A.*(2020). Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error. bioRxiv, https://doi.org/10.1101/2020.02.17.953141. [Full Text] [PDF]

· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.(2019). A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo. bioRxiv, https://doi.org/10.1101/2020.02.24.962282. [Full Text] [PDF]

· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Wu, R., Zhang, S., Pan, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2019). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. bioRxiv, https://doi.org/10.1101/861690. [Full Text] [PDF]

· Kim, H. R., Malik, A. N., Mikhael, J. G., Bech, P., Tsutsui-Kimura, I., Sun, F., Zhang, Y., Li, Y., Watabe-Uchida, M., Gershman, S. J. & Uchida, N.*(2019). A unified framework for dopamine signals across timescales. bioRxiv, https://doi.org/10.1101/803437. [Full Text] [PDF]


· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*. (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431. [Full Text] [PDF]

· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF]

· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics. [Full Text] [PDF]

· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366. [Full Text] [PDF]

* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS . eLife, 8, e45207. [Full Text][PDF]

· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496. [Full Text] [PDF][Suppl Video 1][Suppl Video 2]

* See Viewpoint by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New optical probes bring dopamine to light. Biochemistry, 6379-6381. [Full Text][PDF]

· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737. [Full Text] [PDF][Suppl Figs][Suppl Videos]

* See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648. [Full Text][PDF]

·Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053. [Full Text] [PDF]

· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187. [Full Text] [PDF]


· Kwak, H., Koh, W., Kim, S., Song, K., Shin, J., Lee, J. M., Lee, E. H., Bae, J. Y., Ha, G. E., Oh, J. Park, Y. M., Kim, S., Feng, J., Lee, S. E., Choi, J. W., Kim, K. H., Kim, Y. S., Woo, J., Lee, D., Son, T., Kwon, S. W., Park, K. D., Yoon, B. Lee, J., Li, Y. , Lee, H., Bae, Y. C., Lee, C. J.* & Cheong, E.* (2020). Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron, https://doi.org/10.1016/j.neuron.2020.08.013. [Full Text] [PDF]

·Peng, W.#, Wu, Z.#, Kun, S.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208. [Full Text] [PDF]

·Mazzone, C.M., Liang-Guallpa, J.,Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. A., Reddy, D. M., Sun, F., Zhang, Y., Li, Y., Cui, G. * & Krashes, M. J.* (2020). High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nature Neuroscience, https://doi.org/10.1038/s41593-020-0684-9. [Full Text] [PDF]

·DeGroot, S.R., Zhao-Shea, R., Chung L., Klenowski, P.M., Sun, F., Molas, S., Gardner, P.D., Li, Y. & Tapper, A.R.* (2020). Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2020.06.018. [Full Text] [PDF]

·Zhu, P. K. ,Zheng, W. S. , Zhang, P., Jing, M., Borden, P. M., Ali, F., Guo, K., Feng, J., Marvin, J. S., Wang, Y., Wan, J., Gan, L., Kwan, A. C., Lin, L., Looger, L. L., Li, Y. & Zhang, Y.* (2020). Nanoscopic visualization of restricted nonvolume cholinergic and monoaminergic transmission with genetically encoded sensors. Nano Lett., https://doi.org/10.1021/acs.nanolett.9b04877 [Full Text] [PDF]

· Lin, R.*, Liang, J., Wang, R., Yan, T., Zhou, Y., Liu, Y., Feng, Q., Sun, F., Li, Y., Li, A., Gong, H., & Luo, M.* (2020). The raphe dopamine system controls the expression of incentive memory. Neuron, 1420-19. [Full Text] [PDF]

· Zhang, X., Noyes, N. C. , Zeng, J., Li, Y. & Davis, R. L.* (2019). Aversive training induces both pre- and postsynaptic suppression in Drosophila. The Journal of Neuroscience, 1420-19. [Full Text] [PDF]

· Handler, A., Graham, T. G. M., Cohn, R., Morantte, I., Siliciano, A. F., Zeng J., Li, Y. & Ruta, V.* (2019). Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning. Cell, 178(1), 60-75. [Full Text] [PDF]

· Liang, X., Ho, M. C., Zhang, Y., Li, Y., Wu, M. N., Holy, T. E., & Taghert, P. H.*  (2019). Morning and evening circadian pacemakers independently drive premotor centers via a specific dopamine relay. Neuron, 102(4), 843-857. [Full Text] [PDF]

· Zhou, M.#, Chen, N.#, Tian, J., Zeng, J., Zhang, Y., Zhang, X., Guo, J., Sun, J., Li, Y., Guo, A.*, & Li, Y.* (2019). Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning. PNAS, 201812342. [Full Text] [PDF]

· Li, B.#, Wong, C.#, Gao, S. M., Zhang, R., Sun, R., Li, Y., & *Song, Y. (2018). The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. eLife, 7, e38181. [Full Text] [PDF]

· Tanaka, M., Sun, F., Li, Y., & Mooney, R.* (2018). A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. Nature, 563(7729), 117-120. [Full Text] [PDF][Extended data][Supplementary information]

· Chen, B.#, Huang, X.#, Gou, D., Zeng, J., Chen , G., Pang, M., Hu, Y., Zhao, Z., Wu, H., Cheng, H., Zhang, Z., Xu, C., & Li, Y., Chen, L.*, Wang, A.* (2018). Rapid volumetric imaging with Bessel-Beam three-photon microscopy. Biomedical optics express, 9(4), 1992-2000. [Full Text] [PDF]

· Shen, Y., Ge, W. P., Li, Y., Hirano, A., Lee, H. Y., Rohlmann, A., Missler, M., Tsien, R. W., Jan, L. Y., Fu, Y. H.* & Ptacek, L. J.* (2015). Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences, 112(10), 2935-2941. [Full Text] [PDF]

· Liang, L., Li, Y., Potter, C. J., Yizhar, O., Deisseroth, K., Tsien, R. W., & Luo, L.* (2013). GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron, 79(5), 917-931. [Full Text] [PDF]

· Park, H., Li, Y., & Tsien, R. W.* (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science, 335(6074), 1362-1366. [Full Text] [PDF]

· Yoo, A. S.*, Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien R. W. & Crabtree, G. R.* (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature, 476(7359), 228-231. [Full Text] [PDF]

· Zhang, Q., Li, Y., & Tsien, R. W.* (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science, 323(5920), 1448-1453. [Full Text] [PDF]

· Kuner, T.*, Li, Y., Gee, K. R., Bonewald, L. F., & Augustine, G. J. (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proceedings of the National Academy of Sciences, 105(1), 347-352. [Full Text] [PDF]


· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese) [Full Text] [PDF]

· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008. [Full Text] [PDF]

· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010. [Full Text] [PDF]

· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]

· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap junctions in the nervous system: probing functional connections using new imaging approaches. Frontiers in Cellular Neuroscience, 12, 320. [Full Text] [PDF]

· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. [Full Text] [PDF]

· Wang, A.#, Feng, J.#, Li, Y.*, & Zou, P.* (2018). Beyond fluorescent proteins: hybrid and bioluminescent indicators for imaging neural activities. ACS chemical neuroscience, 9(4), 639-650. [Full Text] [PDF]

· Qian, C., & Li, Y.* (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929. [Full Text] [PDF]

· Li, Y.*, & Rao, Y.* (2015). Pied piper of neuroscience. Cell, 163(2), 267-268. [Full Text] [PDF]