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部分发表论文

[ 实验室代表性论文 | 实验室代表性综述 | 合作代表性论文 | 主要研究论文 | 综述,书评等 | 预印本 | 合作发表论文]

代表性论文(2018至今)

查看 详细信息

/pubfigs/Nature_Touhara_2025.png /pubfigs/NC_Xia_2025.png /pubfigs/Cell_Jun_2024.png /pubfigs/NSR_lv_2024.png /pubfigs/Neuron_Feng_2024.png /pubfigs/Neuron_Umpierre_2024.png /pubfigs/NM_Deng_2024.png
血清素能嗜铬细胞在肠道保护中的作用 (2025) 神经肽与神经递质释放的不同调控规律 (2025) 胆汁淤积瘙痒机制及治疗对策 (2024) 章鱼胺在厌恶性学习中的作用 (2024) 新一代去甲肾上腺素探针 (2024) UDP探针 (2024) 新一代五羟色胺探针 (2024)
/pubfigs/NM_Zhuo_2024.png /pubfigs/Science_Wang_2024.png /pubfigs/PNAS_Wu_2023.png /pubfigs/Neuron_Dong_2023.png /pubfigs/Neuron_Zeng_2023.png /pubfigs/NBT_Qian_2023.png /pubfigs/Neuron_Wu_2021.png
新一代多巴胺探针 (2024) 神经肽探针工具包 (2023) 腺苷释放机制 (2023) 第一代组胺探针 (2023) 五羟色胺在联想学习中的作用 (2023) 第一代催产素探针 (2023) 第一代ATP探针 (2021)
"Best of Neuron 2021-2022"
/pubfigs/NBT_Dong_2021.png /pubfigs/eLife_border.png /pubfigs/NN_Wan_2021.png /pubfigs/NM_Sun_2020.png /pubfigs/NM_Jing_2020.png /pubfigs/eLife_border.png /pubfigs/eLife_border.png
第一代内源大麻素探针 (2021) UDP-glucose 囊泡转运体 (2021) 第一代五羟色胺探针 (2021) 第二代多巴胺探针 (2020) 第二代乙酰胆碱探针 (2020) 痒觉机制 (2019) PARIS (2019)
/pubfigs/Neuron_Feng_2019.png /pubfigs/NIS_Wu_2019.png /pubfigs/Cell_Sun_2019.png /pubfigs/NBT_Jing_2018.png
第一代去甲肾上腺素探针 (2019) GRAB sensors设计
策略
(2019)
第一代多巴胺探针 (2018) 第一代乙酰胆碱探针 (2018)

实验室代表性综述(2015至今)

/pubfigs/COB_Dong_2025.png /pubfigs/ABMBI_Deng_2024.png /pubfigs/CCB_Wan_2024.png /pubfigs/ARAC_Yang_2024.png /pubfigs/JN_Zhao_2024.png /pubfigs/NN_Zheng_2023.png /pubfigs/CON_Qian_2023.png
多巴胺探针的原理,应用和未来 (2025) 宽场成像 (2024) Saxitoxin的光笼合衍生物 (2024) 探针在体应用 (2024) 探针在抑郁症中的应用 (2024) 检测DA的工具 (2023) 检测神经肽的方法 (2023)
/pubfigs/NRN_Wu_2022.png /pubfigs/Cell_Li_2015.png
GRAB探针综述 (2022) 神经生物学的吹笛人 (2015)

合作代表性论文(2018至今)

/pubfigs/NN_Tsutsui_2025.png /pubfigs/CB_Costa_2025.png /pubfigs/PNAS_Straub_2025.png /pubfigs/Nature_Dai_2025.png /pubfigs/NC_Zhang_2025.png /pubfigs/Neuron_Duque_2024.png /pubfigs/Nature_Kalogriopoulos_2024.png
纹状体多巴胺在利害冲突中的作用 (2025) 多巴胺与乙酰胆碱在伏隔核的相关性 (2025) 2-AG释放机制 (2025) 多巴胺与雄性攻击行为 (2025) NE与恐惧环境处理 (2025) 氯胺酮与去甲肾上腺素-星胶可塑性回路 (2024) 可编程抗原门控GPCR (2024)
/pubfigs/MP_Li_2024.png /pubfigs/Cell_Gha_2024.png /pubfigs/Science_Barna_2024.png /pubfigs/Science_Sarah_2024.png /pubfigs/Neuron_Mai_2024.png /pubfigs/Neuron_Zhang_2024.png /pubfigs/Science_Chen_2024.png
星形胶质细胞释放ATP和ADP的机制 (2024) ATP,钙和甜味适应 (2024) 内源大麻素在抑制性突触的信号 (2024) 五羟色胺和情绪感染 (2024) 多光纤阵列检测神经调质 (2024) 乙酰胆碱和催产素相互作用 (2024) 氯胺酮脑区特异性效应 (2024)
/pubfigs/Cell_Sang_2023.png /pubfigs/Neuron_Liao_2023.png /pubfigs/Neuron_DongY_2023.png /pubfigs/CR_Kondev_2023.png /pubfigs/Neuron_Gunduz_2023.png /pubfigs/Cell_Terauchi_2023.png /pubfigs/Nature_Krok_2023.png
睡眠剥夺中前列腺素D2信号 (2023) 下丘脑释放激素和gamma振荡 (2023) 应激缓解中不同的多巴胺释放模式 (2023) 内源大麻素调控应激诱导的行为适应 (2023) 内源大麻素调控恐惧消除 (2023) 投射特异性的信号与分散的多巴胺释放 (2023) 纹状体中多巴胺和乙酰胆碱的自发信号 (2023)
/pubfigs/Neuron_Jasmine_2022.png /pubfigs/CR_Pittolo_2022.png /pubfigs/NBT_Xinyang_2022.png /pubfigs/NN_Lohani_2022.png /pubfigs/Cell_Sheu_2022.png /pubfigs/Nature_Hao_2022.png /pubfigs/Science_Yu_2022.png
五羟色胺调控视网膜信息流 (2022) 多巴胺与星形胶质细胞 (2022) 超灵敏荧光成像 (2022) 乙酰胆碱与新皮质活动 (2022) 五羟色胺信号改变染色质可及性 (2022) 神经紧张素与价态评估 (2022) 应激诱导的睡眠机制 (2022)
/pubfigs/Cell_Deng_2021.png /pubfigs/NC_Guo_2021.png /pubfigs/Science_Simmler_2021.png /pubfigs/NN_Hasani_2021.png /pubfigs/Neuron_Jordan_2021.png /pubfigs/Neuron_Pribiag_2021.png /pubfigs/PNAS_Zhang_2021.png
岛叶-脑干回路中的多巴胺 (2021) 神经群体编码声惊反射 (2021) 五羟色胺对可卡因成瘾的调节作用 (2021) 奖赏增强与VTA中GABA能抑制 (2021) 内源大麻素动态 (2021) DRD3介导的多巴胺释放与可卡因寻求行为 (2021) 胆碱能抑制损害工作记忆 (2021)
/pubfigs/PNAS_Bari_2020.png /pubfigs/Cell_Kim_2020.png /pubfigs/Neuron_Kwak_2020.png /pubfigs/Science_Peng_2020.png /pubfigs/NN_Mazzone_2020.png /pubfigs/NL_Zhu_2020.png /pubfigs/Neuron_Rui_2020.png
不同的去甲肾上腺素蓝斑-额叶皮层通路 (2020) 多巴胺信号的标准框架 (2020) 星形胶质细胞通过持续性抑制调控感官敏锐度 (2020) 腺苷调节睡眠稳态 (2020) 高脂肪食物偏向 (2020) 胆碱能和单胺能传递的纳米尺度可视化 (2020) 蓝斑多巴胺系统调控奖励记忆 (2020)
/pubfigs/JON_Zhang_2019.png /pubfigs/Cell_Handler_2019.png /pubfigs/Neuron_Liang_2019.png /pubfigs/PNAS_Zhou_2019.png /pubfigs/eLife_border.png /pubfigs/Nature_Tanaka_2018.png /pubfigs/BOE_Chen_2018.png
果蝇中厌恶学习诱导的神经抑制 (2019) 联想学习与多巴胺通路 (2019) 多巴胺延迟诱导的生物节律 (2019) GABA能神经元与厌恶性学习 (2019) Notch诱导的神经祖源性肿瘤 (2018) 多巴胺和发声行为 (2018) 3光子显微镜 (2018)

主要研究论文

· K. Touhara*, K., D. Rossen, D., Deng, F., Castro, J., M. Harrington. A., Chu, T., Garcia-Caraballo, S., Brizuela, M., O'Donnell, T., Xu, J., Cil, O., M. Brierley, S.*, Li, Y.* & Julius, D.* (2025) Topological segregation of stress sensors along the gut crypt-villus axis. Nature. [Full Text] [PDF]

· Xia, X., & Li, Y.* (2025) A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release. Nature Communications. [Full Text] [PDF] [Supplemental Data]
[Nature Communications | 新技术-新发现-新想法:李毓龙团队揭秘神经肽-小分子神经递质共同传递在体内的动态差异和调控机制]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2024.05.22.595424v1

· Yang J.#, Zhao, T.#, Fan, J.#, Zou, H.#, Lan, G., Guo, F., Shi, Y., Ke, H., Yu, H., Yue, Z., Wang, X., Bai Y., Li, S., Liu, Y., Wang, X., Chen, Y.*, Li, Y.*, & Lei, X.* (2024) Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell. Volume 187, Issue 25. [Full Text] [PDF] [Supplemental Data]
[Cell | 李毓龙与合作者阐明胆汁淤积瘙痒分子机制,开辟肝病治疗新途径]

· Lv, M., Cai, R., Zhang, R., Xia, X., Li, X., Wang, Y., Wang, H., Zeng, J., Xue, Y., Mao, L., & Li, Y.* (2024). An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning. National Science Review. 11(5): nwae112. [Full Text] [PDF] [Supplemental Data]
[NSR | 李毓龙实验室开发新型探针解析章鱼胺在果蝇厌恶性学习中的时空动态变化及其扮演的重要角色]

See also BioRxiv https://doi.org/10.1101/2024.03.09.584200

· Umpierre, A. D.#*, Li, B.#, Ayasoufi, K., Simon, W. L., Zhao, S., Xie, M., Thyen, G., Hur, B., Zheng, J., Liang, Y., Bosco, D. B., Maynes, M. A., Wu, Z., Yu, X., Sung, J., Johnson, A. J., Li, Y.*, & Wu, L.-J.* (2024) Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron. 112(12): 1959-1977. e10. [Full Text] [PDF] [Supplemental Data] [UDP Release Dynamics ex vivo] [UDP Release Dynamics in vivo]
[Neuron︱梅奥医学中心伍龙军/北京大学李毓龙团队揭示UDP-P2Y6-钙信号通路促进小胶质细胞吞噬能力和神经免疫反应]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.06.12.544691v1

· Feng, J.*, Dong, H., Lischinsky, J. E., Zhou, J., Deng, F., Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., Xie, H., Cui, G., Lin, D., & Li, Y.* (2024). Monitoring norepinephrine release in vivo using next-generation GRABNE sensors. Neuron. 112(12): 1930-1942. e6. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙实验室新升级第二代去甲肾上腺素探针助力活体神经递质研究]

See also BioRxiv https://doi.org/10.1101/2023.06.22.546075

· Deng, F.#, Wan, J.#, Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y., Liu, L., Yan, Y., Feng, J., Zhao, Y., Xie, H., & Li, Y.*(2024). Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo. Nature Methods. 21(4): 692-702. [Full Text] [PDF] [Supplemental Data] [5-HT and Ca2+ Waves During Seizure] [5-HT and eCB Waves During Seizure]
[Nature Methods | 李毓龙实验室升级五羟色胺探针实现超高灵敏度的双色成像]

See also BioRxiv https://www.biorxiv.org/content/biorxiv/early/2023/05/30/2023.05.27.542566.full.pdf

· Zhuo, Y.#, Luo, B.#, Yi, X., Dong, H., Miao, X., Wan, J., Williams, J. T., Campbell, M. G., Cai, R., Qian, T., Li, F., Weber, S. J., Wang, L., Li, B., Wei, Y., Li, G., Wang, H., Zheng, Y., Zhao, Y., Wolf, M. E., Zhu, Y., Watabe-Uchida, M., & Li, Y.* (2024). Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods. 21(4): 680-691. [Full Text] [PDF] [Supplemental Data]
[Nature Methods | 李毓龙实验室新升级第三代红绿多巴胺探针工具包上线]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.08.24.554559v1

· Wang, H.#, Qian, T.#, Zhao, Y., Zhuo, Y., Wu, C., Osakada, T., Chen, P., Chen, Z., Ren, H., Yan, Y., Geng, L., Fu, S., Mei, L., Li, G., Wu, L., Jiang, Y., Qian, W., Zhang, L., Peng, W., Xu, M., Hu, J., Jiang, M., Chen, L., Tang, C., Zhu, Y., Lin, D., Zhou, J.-N., & Li, Y.* (2023). A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors. Science , 382(6672), eabq8173. [Full Text] [PDF] [Supplemental Data] [Distinct SST Spatial Signal Patterns]
[Science | 移花接木——李毓龙实验室设计通用型嫁接策略开发神经肽探针工具包]

See also BioRxiv https://doi.org/10.1101/2022.03.26.485911

· Wu, Z.#, Cui, Y.#, Wang, H.#, Wu, H., Wan, Y., Li, B., Wang, L., Pan, S., Peng, W., Dong, A., Yuan, Z., Jing, M., Xu, M., Luo, M.*, & Li, Y.* (2023). Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor. Proceedings of the National Academy of Sciences, 120(14), e2212387120. [Full Text] [PDF] [Supplemental Data]
[PNAS | 新技术-新发现-新想法:李毓龙团队与合作者揭示“神经调质”腺苷的释放及调控机制]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.05.04.075564

· Dong, H.#, Li, M.#, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R., & Li, Y.* (2023). Genetically encoded sensors for measuring histamine release both in vitro and in vivo. Neuron. 111(10): 1564-1576. e6. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙团队利用新型GRAB探针,解析组胺在睡眠-觉醒过程中的动态变化]

See also BioRxiv https://doi.org/10.1101/2022.08.19.504485

· Zeng, J.#*, Li, X.#, Zhang, R., Lv, M., Wang, Y., Tan, K., Xia, X., Wan, J., Jing, M., Zhang, X., Li, Y., Yang, Y., Wang, L., Chu, J., Li, Y., & Li, Y.*. (2023). Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning. Neuron. 111(7): 1118-1135. e5. [Full Text] [PDF] [Supplemental Data]
[Neuron | 李毓龙团队发现五羟色胺调节关联学习记忆的时间窗口,揭开巴甫洛夫留下的百年之谜]

See also BioRxiv https://doi.org/10.1101/2022.03.27.485970

· Qian, T.#, Wang, H.#, Wang, P.#, Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., & Li, Y.* (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments. Nature Biotechnology. 41(7): 944-957. [Full Text] [PDF] [Supplemental Data] [OT Signals in the VTA During Mating] [OT Signals in the PVN During Mating] [OT Signals in the PFC During Mating]
[Nature Biotechnology | 李毓龙实验室开发新型催产素荧光探针,揭秘神经肽的时空动态调控]

See also BioRxiv https://doi.org/10.1101/2022.02.10.480016

· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Wang, H., Du, J., Jing, M., & Li, Y.* (2021). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo Neuron, 110(5), 770-782.e775. [Full Text] [PDF] [Supplemental Data]

* See Comments Highlight by: Umpierre, A. D., Haruwaka, K., & Wu, L.-J.* (2022). Getting a sense of ATP in real time. Neuroscience Bulletin. [Full Text] [PDF] [ATP and Microglia Dynamics in Zebrafish] [ATP Release During Inflammation in Mice]
[Neuron | 李毓龙实验室开发新型GRAB荧光探针用于检测胞外ATP的时空动态变化]
入选"Best of Neuron 2021-2022"

See also BioRxiv https://doi.org/10.1101/2021.02.24.432680

· Dong, A., He, K., Dudok, B., Farrell, J. S., Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Wang, H., Duan, J., Albarran, E., Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y.*. (2021). A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo. Nature Biotechnology. 40(5): 787-798. [Full Text] [PDF] [Supplemental Data] [eCB and Ca2+ Signals During Seizures]
[Nature Biotechnology | 李毓龙实验室开发新型荧光探针用于检测内源大麻素的时空动态变化]

See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.10.08.329169

· Qian, C., Wu, Z., Sun, R., Yu, H., Zeng, J., Rao, Y., & Li, Y. *. (2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife. 10: e65417. https://doi.org/10.7554/eLife.65417. [Full Text] [PDF] [Supplemental Data]
[eLife | 李毓龙实验室发现定位于突触小泡的新型转运体]

See also BioRxiv https://doi.org/10.1101/2020.12.01.405605

· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*. (2021). A genetically encoded sensor for measuring serotonin dynamics. Nature Neuroscience. 24(5): 746-752. https://doi.org/10.1038/s41593-021-00823-7. [Full Text] [PDF] [Supplemental Data] [5-HT Release in Drosophila]
[Nature Neuroscience | 李毓龙实验室开发新型荧光探针实现在体5-羟色胺动态变化的精确检测]

See also BioRxiv https://doi.org/10.1101/2020.02.24.962282

· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020). Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods. 17(11), 1156-1166. [Full Text] [PDF] [Supplemental Data] [Mushroom Body DA Dynamics]
[Nature Methods | 李毓龙实验室合作实现新型红色荧光多巴胺探针和第二代绿色荧光多巴胺探针的开发及应用]

· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J. , Trinh, S., Wu, R., Zhang, S., Pan, S., Hires, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, 17(11), 1139-1146. [Full Text] [PDF] [Supplemental Data]
[Nature Methods | 新一代乙酰胆碱探针实现体内乙酰胆碱信号的精确解析]

· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*. (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431. [Full Text] [PDF] [Supplemental Data]
[eLife | 李毓龙研究组与合作者报道胆汁淤积瘙痒的分子机制]

· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF] [Supplemental Data] [Video Abstract]
[Neuron | 李毓龙研究组报道新型基因编码的去甲肾上腺素荧光探针]

· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics. [Full Text] [PDF]

· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366. [Full Text] [PDF] [Supplemental Data]
[eLife | 李毓龙研究组开发检测缝隙连接的新型光遗传学方法]

* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS. eLife, 8, e45207. [Full Text][PDF]

· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496. [Full Text] [PDF] [Supplemental Data] [DA Signals Under Electrical Stimulation] [DA Signals Under Odor Stimulation]
[央视报道 | 北大生科李毓龙研究组发明新型多巴胺“探针”]

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· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737. [Full Text] [PDF][Supplemental Data] [Supplemental Videos]
[NBT | 北大李毓龙组开发新型乙酰胆碱荧光探针——专家点评]

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综述,书评等

· Dong, H., Wang, Z., & Li, Y.* (2025). Genetically encoded dopamine sensors: principles, applications, and future directions. Current Opinion in Behavioral Sciences. Volume 62, April 2025, 101489. [Full Text] [PDF]

· Deng, F., Feng, J., Xie,H., & Li, Y.* (2025). Mesoscopic Imaging of Neurotransmitters and Neuromodulators with Genetically Encoded Sensors. Awake Behaving Mesoscopic Brain Imaging. Neuromethods, vol 214. Humana, New York. [Full Text] [PDF]

· Wan, J., & Li, Y.* (2024). STX-bpc: “Brightening” the path to neuronal inhibition. Cell Chemical Biology. 31(7): 1233-1235. [Full Text] [PDF]

· Yang, Y.#, Li, B.#, & Li, Y.* (2024). Genetically Encoded Sensors for the In Vivo Detection of Neurochemical Dynamics. Annual Review of Analytical Chemistry. 17. [Full Text] [PDF]

· Zhao, Y., Wan, J., & Li, Y.* (2024). Genetically encoded sensors for in vivo detection of neurochemicals relevant to depression. Journal of Neurochemistry. 17. [Full Text] [PDF]

· Zheng, Y., & Li, Y.* (2023). Past, Present, and Future of Tools for Dopamine Detection. Neuroscience, 525, 13-25. [Full Text] [PDF]

· Qian, T., Wang, H., Xia, X., & Li, Y.* (2023) Current and emerging methods for probing neuropeptide transmission.  Current Opinion in Neurobiology, 81, 102751. [Full Text] [PDF]

· Dong, C.#, Zheng, Y.#, Long-Iyer, K., Wright, E. C., Li, Y.*, & Tian, L.* (2022). Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors. Annual Review of Neuroscience. 45(1): 273-294. [Full Text] [PDF]

· Wu, Z., Lin, D., & Li, Y.* (2022). Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.  Nature Reviews Neuroscience. 23(5): 257-274. [Full Text] [PDF]

· Zhuo, Y., Li, Y.* (2022). New imaging methods for monitoring dopaminergic neurotransmission.  Science China Life Sciences, 65. [Full Text] [PDF]

· Yulong Li. (2021). Neuron, 109(21), 3346-3348. [Full Text] [PDF]

· Yu, H., Wangensteen, K., Deng, T., Li, Y., & Luo, W.* (2021). MRGPRX4 in Cholestatic Pruritus.  Semin Liver Dis41(03), 358-367. [Full Text] [PDF]

· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese) [Full Text] [PDF]

· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008. [Full Text] [PDF]

· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010. [Full Text] [PDF]

· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]

· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap junctions in the nervous system: probing functional connections using new imaging approaches. Frontiers in Cellular Neuroscience, 12, 320. [Full Text] [PDF]

· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. [Full Text] [PDF]

· Wang, A.#, Feng, J.#, Li, Y.*, & Zou, P.* (2018). Beyond fluorescent proteins: hybrid and bioluminescent indicators for imaging neural activities. ACS chemical neuroscience, 9(4), 639-650. [Full Text] [PDF]

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· Li, Y.*, & Rao, Y.* (2015). Pied piper of neuroscience. Cell, 163(2), 267-268. [Full Text] [PDF]

预印本

· Zheng, Y., Cai, R., Wang, K., Zhang, J., Zhuo, Y., Dong, H., Zhang, Y., Wang, Y., Deng, F., Ji, E., Cui, Y., Fang, S., Zhang, X., Zhang, K., Wang, J., Li, G., Miao, X., Wang, Z., Yang, Y., Li, S., Grimm, J., Johnsson, K., Schreiter, E., Lavis, L., Chen, Z., Mu, Y., & Li, Y*. (2024). In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors. bioRxiv. [Full Text] [PDF]

· Xie, S., Miao, X., Li, G., Zheng, Y., Li, M., Ji, E., Wang, J., Li, S., Cai, R., Geng, L., Feng, J., Wei, C.*, & Li, Y*. (2024). Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo. bioRxiv. [Full Text] [PDF]

· Lopez, R., Noble, N., Ozcete, O., Cai, X., Handy, G., Andersen, J., Patriarchi, T., Li, Y*, & Kaeser, P.* (2024). Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors. bioRxiv. [Full Text] [PDF]

· Liu, Y., Nong, Y., Feng, J., Li, G., Sajda, P., Li, Y., & Wang, Q.* (2024). Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control. bioRxiv, 2022.2005.2018.492553. [Full Text] [PDF]

· Zou, J., Willem, J., Mridha, Z., Trinh, S., Erskine, A., Jing, M., Yao, J., Walker, S., Li, Y., McGinley, M., Hires, S.* (2024) Goal-directed motor actions drive acetylcholine dynamics in sensory cortex eLife , 13:RP96931 [Full Text] [PDF]

· Fan, J., Wang, Y., Li, L., He, J., Zhao, Z., Deng, F., Li, G, Li X., Zhou, Y., Zhao, J., Li, Y., Wu, J., Fang, L., & Dai, Q* (2024). Prominent involvement of acetylcholine in shaping stable olfactory representation across the Drosophila brain. bioRxiv, 2024.04.03.587915. [Full Text] [PDF]

· Wang T., Zhang X., Duan H., Xia D., Li T., Yan R., Zhan Y., Li, Y., Gao W., & Zhou, Q.* (2024). Gating of Memory to Behavior by the Locus Coeruleus. bioRxiv, 2024.01.09.574947. [Full Text] [PDF]

· Ai M., Takeshi K., Naoki N., Yuka T., Yoan C., Yukiko I., Li, Y., Hotaka T., Jun S., Masashi Y., Takeshi S., Katsuyasu S., & Liu, Q.* (2024). Sequential Transitions of Male Sexual Behaviors Driven by Dual Acetylcholine-Dopamine Dynamics. bioRxiv, 2023.12.21.572798. [Full Text] [PDF]

· Sun, D., Ng, S., Zheng, Y., Xie, S. , Schwan, N., Breuer P., Hoffmann, D., Michel, J., Azorin, D., Boonekamp, K., Winkler, F., Wick, W., Boutros, M., Li, Y., & Johnsson, K.* (2024). Molecular recording of cellular protein kinase activity with chemical labeling. bioRxiv, 2024.09.11.611894. [Full Text] [PDF]

· Ge, C., Chen, Z., Sun, F., Hou, R., Fan, H., Li, Y., & Li, C.* (2024). Timing-dependent modulation of working memory by VTA dopamine release in medial prefrontal cortex. bioRxiv, 2024.09.11.611894. [Full Text] [PDF]

· Wu, Y., Gu, X., Kong, Y., Yang, S., Wang, H., Xu, M., Wang, Q., Yi, X., Lin, Z., Jiao, Z., Cheung, H., Zhao, X., Bian, X., Jiang, Q., Li, Y., Zhu, M., Wang, L., Li, Y., Huang, J., Li, Q., Li, W., & Xu, T.* (2024). Neuropeptide Y co-opts neuronal ensembles for memory lability and stability. bioRxiv, 2024.05.09.593455. [Full Text] [PDF]

· Wang, H., Ortega, H., Kelly, E., Indajang, E., Feng, J. , Li, Y., & Kwan, A.* (2024). Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making. bioRxiv, 2024.01.23.576893. [Full Text] [PDF]

· Garcia, S., Laffere, A., Toschi, C., Schilling, L., Podlaski, J., Fritsche, M., Zatka-Haas, P., Li, Y., Bogacz, R., Saxe, A., & Lak, A.* (2023). Striatal dopamine reflects individual long-term learning trajectories. bioRxiv, 2023.12.14.571653. [Full Text] [PDF]

· Guo, Q., Hou, T., Xie, W., Zhang, J., Ma, X., Guo, Y., Wang, X., Wang, L., Lu, M., Wu, Z, Wang, H., Chen, Y., Li, Y., & Wang, S.*(2024). Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria. bioRxiv, 2024.09.30.615983. [Full Text] [PDF]

· Yang, J., Basu, A., Liu, R., Staszko, S., Yu, A., Rondeau, J., Glaeser-Khan, S., Feng, J., Li, Y., Che, A., & Kaye, A.* (2023). Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model. bioRxiv, 2023.11.27.568929. [Full Text] [PDF]

· Touhara, K., Rossen, N., Deng, F., Chu, T., Harrington, A., Caraballo, S., Brizuela, M., O'Donnell, T., Cil, O., Brierley, S., Li, Y., & Julius, D.* (2024). Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut. bioRxiv, 2024.02.06.579180. [Full Text] [PDF]

· Singh, S., Sarroza, D., English, A., Whittington, D., Dong, A., van der Stelt, M., Li, Y., Zweifel, L., Bruchas, M. R., Land, B. B., & Stella, N.* (2022). ABHD6 selectively controls metabotropic-dependent increases in 2-AG production. bioRxiv, 2024.2005.2017.594562. [Full Text] [PDF]

· Jiang, P.*, Kemper, K. M., Chang, K.-T., Qian, C., Li, Y., Guan, L., van Hasselt, P., Caradonna, S. J., & Strich, R. (2022). An in situ cut-and-paste genome editing platform mediated by CRISPR/Cas9 or Cas12a. bioRxiv, 2022.2003.2030.486486. [Full Text] [PDF]

· Zou, J., Trinh, S., Erskine, A., Jing, M., Yao, J., Walker, S., Li, Y.., & Hires, S. A.* (2021). Directed motor actions and choice signalling drive cortical acetylcholine dynamics. bioRxiv,, 2021.2012.2021.473699. [Full Text] [PDF]

· Sturgill, J. F., Hegedus, P., Li, S. J., Chevy, Q, Siebels, A., Jing, M., Li, Y., Hangya, B.* & Kepecs, A.*(2020). Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error. bioRxiv, 2020.02.17.953141. [Full Text] [PDF]

合作发表论文

· Tsutsui-Kimura, I., Tian, Z., Amo, R., Zhuo, Y., Li, Y., Campbell, M., Uchida, N., & Watabe-Uchida, M.* (2025) Dopamine in the tail of the striatum facilitates avoidance in threat-reward conflicts. Nature Neuroscience. [Full Text] [PDF]

· Costa, K.*, Zhang, Z.*, Deutsch, D., Zhuo, Y., Li, G., Li, Y., & Schoenbaum, G.* (2025) Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states. Current Biology. [Full Text] [PDF]

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· Straub, V., Barti, B., Tandar, S., Stevens, A., van der Wel, T., Zhu, N., Rüegger, J., van der Horst, C., Heitman, L. Li, Y., Stella, N., van Hasselt, J. G., Coen Katona, I., & van der Stelt, M.* (2025) The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles. PNAS. 122 (8) e2421717122. [Full Text] [PDF]

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· Dai,B. , Zheng, B., Dai, X., Cui, X., Yin, L., Cai, J., Zhuo, Y., Tritsch, N., Zweifel, L., Li, Y. & Lin, D.* (2024) Experience-dependent dopamine modulation of male aggression. Nature. [Full Text] [PDF]

· Zhang, E., Saglimbeni, G., Feng, J. , Li, Y. & Bruchas, M.* (2024) Dentate gyrus norepinephrine ramping facilitates aversive contextual processing. Nature Communications. [Full Text] [PDF]

· Duque, M., Chen, A., Hsu, E., Narayan, S., Rymbek, A., Begum, S., Saher, G., Cohen, A., Olson, D., Li, Y., Prober, D., Bergles, D., Fishman, M., Engert, F., & Ahrens, M.* (2024) Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Neuron. [Full Text] [PDF]

· Ji, E., Zhang, Y., Li, Z. , Wei, L., Wu, Z., Li, Y., Yu, X. & Song, T. (2024) The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking. Neuroscience Bulletin. [Full Text] [PDF]

· Kalogriopoulos, N., Tei, R., Yan, Y., Klein, P., Ravalin, M., Cai, B., Soltesz, I., Li, Y., & Ting, A.* (2024) Synthetic GPCRs for programmable sensing and control of cell behaviour. Nature. [Full Text] [PDF]

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· Li, H., Zhao, Y., Dai, R. , Geng, P., Weng, D., Wu, W., Yu, F., Lin, R., Wu, Z. , Li, Y., & Luo, M.* (2024) Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis. Molecular Psychiatry. [Full Text] [PDF]

· Park, G., Lee, G., Yoon, J., Han, J., Choi, P., Kim, M., Lee, S., Park, C., Wu, Z. , Li, Y., & Choi, M.* (2024) Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation. Cell. [Full Text] [PDF]

· Cai, X., Liu, C., Tsutsui-Kimura, I., Lee, J., Guo, C., Banerjee, A., Lee, J., Amo, R., Xie, Y., Patriarchi, T., Li, Y., Watabe-Uchida, M., Uchida, N., & Kaeser, P.* (2024) Dopamine dynamics are dispensable for movement but promote reward responses. Nature. [Full Text] [PDF]

· Neyhart, E., Zhou, N., Munn, B., Law, R., Smith, C., Mridha, Z., Blanco, F., Li,G. , Li, Y., Hu, M., McGinley, M., Shine, J., & Reimer, J.*(2024) Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state. Cell Reports, Vol 43, Issue 10. [Full Text] [PDF]

· Berki, P., Cserép, C., Környei, Z., Pósfai, B., Szabadits, E., Domonkos, A., Kellermayer, A., Nyerges, M., Wei, X., Mody, I., Kunihiko, A., Beck, H., He K., Wang Y., Lénárt, N., Wu, Z., Jing, M., Li, Y., Gulyás, A., & Dénes, A.*(2024) Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices. Nature Communications, Vol. 15, Issue 1. [Full Text] [PDF]

· Chen, M., Ma, S., Liu, H., Dong, Y., Tang, J., Ni, Z., Tan, Y., Duan, C., Li, H., Huang, H., Li, Y., Cao, X., J. Lingle, C., Yang Y., & Hu, H.*(2024) Brain region–specific action of ketamine as a rapid antidepressant. Science, Vol 385, Issue 6709. [Full Text] [PDF]

· Mondoloni, S., Molina, P., Lecca, S., Wu C., Michel, L., Osypenko, D., Cachin, F., Flanigan, M., Congiu, M., L. Lalive, A., Kash, T., Deng, F., Li, Y., & Mameli, M.*(2024) Serotonin release in the habenula during emotional contagion promotes resilience. Science, 1081-1086 . [Full Text] [PDF]

· Singh, S., Sarroza, D., English, A., Whittington, D., Dong, A., Malamas, M., Makriyannis, A., van der Stelt, M., Li, Y., Zweifel, L., Bruchas, M. R., Land, B. B., & Stella, N.* (2024) P2X7 receptor-dependent increase in endocannabinoid 2-arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism. British Journal of Pharmacology, 1–19. [Full Text] [PDF]

· Basu, A., Yang, J.-H., Yu, A., Glaeser-Khan, S., Rondeau, J. A., Feng, J., Krystal, J. H., Li, Y., & Kaye, A. P.* (2024). Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry. [Full Text] [PDF]

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· Glaeser-Khan, S., Savalia, N., Cressy, J., Feng, J., Li, Y., Kwan, A., & Kaye, A.* (2024). Spatiotemporal organization of prefrontal norepinephrine influences neuronal activity. eNeuro. 11(5). [Full Text] [PDF]

· Roy, K., Zhou, X., Otani, R., Yuan, P., Ioka, S., Vogt, K., Kondo, T., Farag, N., Ijiri, H., Wu, Z., Chitose, Y., Amezawa, M., Uygun, D., Cherasse, Y., Nagase, H., Li, Y., Yanagisawa, M., Abe, M., Basheer, R., Wang, Y.*, Saitoh, T.*, & Lazarus, M.* (2024). Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications. 15, 3661. [Full Text] [PDF]

· Zhang, Y.#, Karadas, M.#, Liu, J., Gu, X., Vöröslakos, M., Li, Y., Tsien, R. W., & Buzsáki, G.* (2024). Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus. Neuron, S0896-6273(24)00154-5. [Full Text] [PDF]

· Dudok, B.#*, Fan, L. Z.#, Farrell, J. S., Malhotra, S., Homidan, J., Kim, D. K., Wenardy, C., Ramakrishnan, C., Li, Y., Deisseroth, K., & Soltesz, I.* (2024). Retrograde endocannabinoid signaling at inhibitory synapses in vivo. Science, 383(6686), 967-970. [Full Text] [PDF]

· Tokumaru, T., Apolinario, M., Shimizu, N., Umeda, R., Honda, K., Shikano, K., Teranishi, H., Hikida, T., Hanada, T., Ohta, K., Li, Y., Murakami, K., & Hanada, R.* (2024). Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease. Scientific Reports, 14, 7813. [Full Text] [PDF]

· Vu, M., Brown, E., Wen, M., Noggle, C., Zhang, Z,, Monk, K., Bouabid, S., Mroz, L., Graham, B., Zhuo, Y., Li, Y., Otchy, T., Tian, L, Davison, I., Boas, D., & Howe, M.* (2024). Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior. Neuron, Vol 112, Issue 6. [Full Text] [PDF]

· Bayazitov, I., Teubner, B., Feng F., Wu, Z., Li, Y., Blundon, J., & Zakharenko, S.* (2024). Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning. Cell Reports, Vol 43, Issue 2. [Full Text] [PDF]

· Cai, J., Jiang, Y., Xu, Y., Jiang, Z., Young, C., Hongli L., Ortiz-Guzman, J., Zhuo, Y,, Li, Y., Yong X., Arenkiel, B., & Tong, Q.* (2024). An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes. Neuron.. Vol 112, Issue 3. [Full Text] [PDF]

· Zhou, X.#, He, Y.#, Xu, T.#, Wu, Z.#, Guo, W., Xu, X., Liu, Y., Zhang, Y., Shang, H., Huang, L., Yao, Z., Li, Z., Su, L., Li, Z., Feng, T., Zhang, S., Monteiro, O., Cunha, R. A., Huang, Z.-L., Zhang, K.*, Li, Y., Cai, X.*, Qu, J.*, & Chen, J.-F.* (2024). 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Research.. [Full Text] [PDF]

· Gyawali, U., Martin, D. A., Sun, F., Li, Y., & Calu, D.* (2023). Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations. eLife, 12. [Full Text] [PDF]

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· Mayer, F. P.*, Niello, M., Cintulova, D., Sideromenos, S., Maier, J., Li, Y., Bulling, S., Kudlacek, O., Schicker, K., Iwamoto, H., Deng, F., Wan, J., Holy, M., Katamish, R., Sandtner, W., Li, Y., Pollak, D. D., Blakely, R. D., Mihovilovic, M. D., Baumann, M. H., & Sitte, H. H.* (2023). Serotonin-releasing agents with reduced off-target effects. Molecular Psychiatry, 28(2), 722-732. [Full Text] [PDF]

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· Hatashita, Y., Wu, Z., Fujita, H., Kumamoto, T., Livet, J., Li, Y., Tanifuji, M., & Inoue, T.* (2023). Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses. Glia , 71(9), 2250-2265. [Full Text] [PDF]

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· Singh, S., Sarroza, D., English, A., McGrory, M., Dong, A., Zweifel, L., Land, B. B., Li, Y., Bruchas, M. R., & Stella, N.* (2023). Pharmacological Characterization of the Endocannabinoid Sensor GRABeCB2.0. Cannabis and Cannabinoid Research.. [Full Text] [PDF]

· Sang, D.#, Lin, K.#, Yang, Y.#, Ran, G., Li, B., Chen, C., Li, Q., Ma, Y., Lu, L., Cui, X.-Y., Liu, Z., Lv, S.-Q., Luo, M., Liu, Q., Li, Y., & Zhang, E. E.* (2023). Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals. Cell, 186(25), 5500-5516.e5521. [Full Text] [PDF]

· Liao, Y.#, Wen, R.#, Fu, S., Cheng, X., Ren, S., Lu, M., Qian, L., Luo, F., Wang, Y., Xiao, Q., Wang, X., Ye, H., Zhang, X., Jiang, C., Li, X., Li, S., Dang, R., Liu, Y., Kang, J., Yao, Z., Yan, J., Xiong, J., Wang, Y., Wu, S., Chen, X., Li, Y., Xia, J.*, Hu, Z.*, & He, C.* (2023) Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations. Neuron. . [Full Text] [PDF]

· Dong, Y., Li, Y., Xiang, X., Xiao, Z. C., Hu, J., Li, Y., Li, H., & Hu, H.* (2023). Stress relief as a natural resilience mechanism against depression-like behaviors. Neuron. [Full Text] [PDF]

· Kondev, V., Najeed, M., Yasmin, F., Morgan, A., Loomba, N., Johnson, K., Adank, D. N., Dong, A., Delpire, E., Li, Y., Winder, D., Grueter, B. A., & Patel, S.* (2023). Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation. Cell Reports, 113027. [Full Text] [PDF]

· Hasegawa, E., Li, Y., & Sakurai, T.* (2023). Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala. Neuroscience Research. [Full Text] [PDF]

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