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· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Wang, H., Du, J., Jing, M., & Li, Y.* (2021). An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. bioRxiv, https://doi.org/10.1101/2021.02.24.432680. [Full Text] [PDF]

· Huang, M.#, Li, D.#, Pei, Q.#, Xie, Z., Gu, H., Liu, A., Chen, Z., Wang, Y., Sun, F., Li, Y., Zhang, J., He, M., Xie, Y., Zhang, F., Qi, X., Shang, C.*, & Cao, P.*(2020). The SC-SNc pathway boosts appetitive locomotion in predatory hunting. bioRxiv, https://doi.org/10.1101/2020.11.23.395004. [Full Text] [PDF]

· Lohani, S.#, Moberly, A. H.#, Benisty, H., Landa, B., Jing, M., Li, Y., Higley, M. J.*, & Cardin, J. A.* (2020). Dual color mesoscopic imaging reveals spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. bioRxiv, https://doi.org/10.1101/2020.12.09.418632. [Full Text] [PDF]

· Qian, C., Wu, Z., Sun, R., Yu, H., Zeng, J., Rao, Y., & Li, Y. *. (2020). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. bioRxiv, https://doi.org/10.1101/2020.12.01.405605. [Full Text] [PDF]

· Dong, A.,He, K., Dudok, B., Farrell, J. S., Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Duan, J., Albarran, E., Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y. * (2020). A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo. bioRxiv, https://doi.org/10.1101/2020.10.08.329169. [Full Text] [PDF]

· Gallo, E. F.*, Greenwald, J., Teboul, E., Martyniuk, K. M., Li, Y., Javitch, J. A., Balsam, P. D. & Kellendonk C.* (2020). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. bioRxiv, https://doi.org/10.1101/2020.09.07.284612. [Full Text] [PDF]

· Kjaerby, C.#*, Andersen, M.#, Hauglund, N., Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, K. P., Feng, J., Li, Y. , Weikop, P., Hirase, H.& Nedergaard, M.* (2020). Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions. bioRxiv, https://doi.org/10.1101/2020.09.01.274977. [Full Text] [PDF]

· Hamilos, A. E., Spedicato, G. Hong, Y., Sun, F., Li, Y. & Assad, J. A.* (2020). Dynamic dopaminergic activity controls the timing of self-timed movement. bioRxiv, https://doi.org/10.1101/2020.05.13.094904. [Full Text] [PDF]

· Wu, Z., Cui, Y., Wang, H., Song, K., Yuan, Z., Dong, A., Wu, H., Wan, Y., Pan, S., Peng, W., Jing, M., Xu, M., Luo, M. & Li, Y. * (2020). A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release. bioRxiv, https://doi.org/10.1101/2020.05.04.075564. [Full Text] [PDF]

· Sturgill, J. F., Hegedus, P., Li, S. J., Chevy, Q, Siebels, A., Jing, M., Li, Y., Hangya, B.* & Kepecs, A.*(2020). Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error. bioRxiv, https://doi.org/10.1101/2020.02.17.953141. [Full Text] [PDF]


· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.(2021). A genetically encoded sensor for measuring serotonin dynamics. Nature Neuroscience, https://doi.org/10.1038/s41593-021-00823-7. [Full Text] [PDF]
See also BioRxiv https://doi.org/10.1101/2020.02.24.962282.

· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020). Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods, https://doi.org/10.1038/s41592-020-00981-9. [Full Text] [PDF]

· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Wu, R., Zhang, S., Pan, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, https://doi.org/10.1038/s41592-020-0953-2. [Full Text] [PDF]

· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*. (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431. [Full Text] [PDF]

· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF]

· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics. [Full Text] [PDF]

· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366. [Full Text] [PDF]

* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS. eLife, 8, e45207. [Full Text][PDF]

· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496. [Full Text] [PDF][Suppl Video 1][Suppl Video 2]

* See Viewpoint by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New optical probes bring dopamine to light. Biochemistry, 6379-6381. [Full Text][PDF]

· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737. [Full Text] [PDF][Suppl Figs][Suppl Videos]

* See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648. [Full Text][PDF]

· Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053. [Full Text] [PDF]

· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187. [Full Text] [PDF]


· Zhang, Y.#, Cao, L.#, Varga, V., Jing, M., Karadas, M., Li, Y., & Buzsáki, G.* (2021). Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory. Proceedings of the National Academy of Sciences, 118(15), e2016432118. https://doi.org/10.1073/pnas.2016432118. [Full Text] [PDF]

· Bai, J., Guo, F., Li, M., Li, Y.*, & Lei, X.* (2021). Click-based amplification: designed to facilitate various target labelling with ultralow background. RSC Chemical Biology, https://doi.org/10.1039/D1CB00002K. [Full Text] [PDF]

· Zeng, Y.#, Luo, H.#, Gao, Z., Zhu, X., Shen, Y., Li, Y., Hu, J.*, & Yang, J.* (2021). Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine. iScience,24(3), 102213. https://doi.org/https://doi.org/10.1016/j.isci.2021.102213. [Full Text] [PDF]

· Sethuramanujam, S.#, Matsumoto, A.#, deRosenroll, G., Murphy-Baum, B., McIntosh, J. M., Jing, M., Li, Y., Berson, D., Yonehara, K.*, & Awatramani, G. B.* (2021). Rapid multi-directed cholinergic transmission in the central nervous system. Nature Communications, https://doi.org/10.1038/s41467-021-21680-9. [Full Text] [PDF]
See also BioRxiv https://doi.org/10.1101/2020.04.18.048330.

· Wang, J.#, Li, J.#, Yang, Q.#, Xie, Y.-K., Wen, Y.-L., Xu, Z.-Z., Li, Y., Xu, T., Wu, Z.-Y., Duan, S., & Xu, H.* (2021). Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. Proceedings of the National Academy of Sciences,118(7), e2019295118. https://doi.org/10.1073/pnas.2019295118. [Full Text] [PDF]

· Song, Y., Xu, C., Liu, J., Li, Y., Wang, H., Shan, D., Wainer Irving, W., Hu, X., Zhang, Y.*, Woo Anthony, Y.-H.*, & Xiao, R.-P. Heterodimerization with 5-HT2BR Is Indispensable for β2AR-mediated Cardioprotection. Circulation Research, https://doi.org/10.1161/CIRCRESAHA.120.317011. [Full Text] [PDF]

· Zhu, R.#, Zhang, G.#, Jing, M., Han, Y., Li, J., Zhao, J., Li, Y., & Chen, P. R.* (2021, 2021/01/25). Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nature Communications,,12(1), 581. https://doi.org/10.1038/s41467-020-20754-4. [Full Text] [PDF]

· Mayer, F. P., Iwamoto, H., Hahn, M. K., Grumbar, G. J., Stewart, A., Li, Y., & Blakely, R. D.* (2021). There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens. Neurochemistry International, 142, 104894. https://doi.org/https://doi.org/10.1016/j.neuint.2020.104894. [Full Text] [PDF]

· Bari*, A., Xu, S., Pignatelli, M., Takeuchi, D., Feng, J., Li, Y., & Tonegawa, S.* (2020). Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways. Proceedings of the National Academy of Sciences, https://doi.org/10.1073/pnas.2015635117. [Full Text] [PDF]

· Kim, H. R.*, Malik, A. N., Mikhael, J. G., Bech, P., Tsutsui-Kimura, I., Sun, F., Zhang, Y., Li, Y., Watabe-Uchida, M., Gershman, S. J., & Uchida, N.* (2020). A Unified Framework for Dopamine Signals across Timescales. Cell, https://doi.org/https://doi.org/10.1016/j.cell.2020.11.013. [Full Text] [PDF]

· Crouse,R. B., Kim, K., Batchelor, H. M., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D A., Jing, M. , Li, Y., Gao, X., Mineur , Y. S., & Picciotto, M. R. * (2020). Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. eLife, 9:e57335. [Full Text] [PDF]

· Kwak, H., Koh, W., Kim, S., Song, K., Shin, J., Lee, J. M., Lee, E. H., Bae, J. Y., Ha, G. E., Oh, J. Park, Y. M., Kim, S., Feng, J., Lee, S. E., Choi, J. W., Kim, K. H., Kim, Y. S., Woo, J., Lee, D., Son, T., Kwon, S. W., Park, K. D., Yoon, B. Lee, J., Li, Y. , Lee, H., Bae, Y. C., Lee, C. J.* & Cheong, E.* (2020). Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron, https://doi.org/10.1016/j.neuron.2020.08.013. [Full Text] [PDF]

· Peng, W.#, Wu, Z.#, Kun, S.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208. [Full Text] [PDF]

· Mazzone, C.M., Liang-Guallpa, J.,Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. A., Reddy, D. M., Sun, F., Zhang, Y., Li, Y., Cui, G. * & Krashes, M. J.* (2020). High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nature Neuroscience, https://doi.org/10.1038/s41593-020-0684-9. [Full Text] [PDF]

· DeGroot, S.R., Zhao-Shea, R., Chung L., Klenowski, P.M., Sun, F., Molas, S., Gardner, P.D., Li, Y. & Tapper, A.R.* (2020). Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2020.06.018. [Full Text] [PDF]

· Zhu, P. K. ,Zheng, W. S. , Zhang, P., Jing, M., Borden, P. M., Ali, F., Guo, K., Feng, J., Marvin, J. S., Wang, Y., Wan, J., Gan, L., Kwan, A. C., Lin, L., Looger, L. L., Li, Y. & Zhang, Y.* (2020). Nanoscopic visualization of restricted nonvolume cholinergic and monoaminergic transmission with genetically encoded sensors. Nano Lett., https://doi.org/10.1021/acs.nanolett.9b04877. [Full Text] [PDF]

· Lin, R.*, Liang, J., Wang, R., Yan, T., Zhou, Y., Liu, Y., Feng, Q., Sun, F., Li, Y., Li, A., Gong, H., & Luo, M.* (2020). The raphe dopamine system controls the expression of incentive memory. Neuron, 1420-19. [Full Text] [PDF]

· Zhang, X., Noyes, N. C. , Zeng, J., Li, Y. & Davis, R. L.* (2019). Aversive training induces both pre- and postsynaptic suppression in Drosophila. The Journal of Neuroscience, 1420-19. [Full Text] [PDF]

· Handler, A., Graham, T. G. M., Cohn, R., Morantte, I., Siliciano, A. F., Zeng J., Li, Y. & Ruta, V.* (2019). Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning. Cell, 178(1), 60-75. [Full Text] [PDF]

· Liang, X., Ho, M. C., Zhang, Y., Li, Y., Wu, M. N., Holy, T. E., & Taghert, P. H.*  (2019). Morning and evening circadian pacemakers independently drive premotor centers via a specific dopamine relay. Neuron, 102(4), 843-857. [Full Text] [PDF]

· Zhou, M.#, Chen, N.#, Tian, J., Zeng, J., Zhang, Y., Zhang, X., Guo, J., Sun, J., Li, Y., Guo, A.*, & Li, Y.* (2019). Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning. Proceedings of the National Academy of Sciences, 201812342. [Full Text] [PDF]

· Li, B.#, Wong, C.#, Gao, S. M., Zhang, R., Sun, R., Li, Y., & *Song, Y. (2018). The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. eLife, 7, e38181. [Full Text] [PDF]

· Tanaka, M., Sun, F., Li, Y., & Mooney, R.* (2018). A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. Nature, 563(7729), 117-120. [Full Text] [PDF][Extended data][Supplementary information]

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· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese) [Full Text] [PDF]

· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008. [Full Text] [PDF]

· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010. [Full Text] [PDF]

· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]

· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap junctions in the nervous system: probing functional connections using new imaging approaches. Frontiers in Cellular Neuroscience, 12, 320. [Full Text] [PDF]

· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. [Full Text] [PDF]

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