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Selected Publications
[ Featured Lab Articles
| Featured Reviews or Previews
| Featured Collaborative Articles
| Main Research Articles
| Reviews, Book Chapters and Highlights
| Pre-prints
| Collaborative Publication]
Featured Lab Research Articles (2018- )
See more details
Featured Reviews or Previews (2015- )
Featured Collaborative Papers (2018- )
Main Research Articles
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· Xia, X., & Li, Y.* (2025) A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release.
Nature Communications.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2024.05.22.595424v1
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· Yang J.#, Zhao, T.#, Fan, J.#, Zou, H.#, Lan, G., Guo, F., Shi, Y., Ke, H., Yu, H., Yue, Z., Wang, X., Bai Y., Li, S., Liu, Y., Wang, X., Chen, Y.*, Li, Y.*, & Lei, X.* (2024) Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
Cell. Volume 187, Issue 25.
[Full Text]
[PDF]
[Supplemental Data]
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· Lv, M., Cai, R., Zhang, R., Xia, X.,
Li, X., Wang, Y., Wang, H., Zeng, J., Xue, Y., Mao, L., & Li, Y.* (2024).
An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.
National Science Review. 11(5): nwae112.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2024.03.09.584200
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· Umpierre, A. D.#*, Li, B.#, Ayasoufi, K., Simon, W. L.,
Zhao, S., Xie, M., Thyen, G., Hur, B., Zheng, J., Liang, Y., Bosco, D. B., Maynes, M. A., Wu, Z.,
Yu, X., Sung, J., Johnson, A. J., Li, Y.*, & Wu, L.-J.* (2024)
Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune
responses in epileptogenesis.
Neuron. 112(12): 1959-1977. e10.
[Full Text]
[PDF]
[Supplemental Data]
[UDP Release Dynamics ex vivo]
[UDP Release Dynamics in vivo]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.06.12.544691v1
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· Feng, J.*, Dong, H., Lischinsky, J. E., Zhou, J., Deng, F.,
Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., Xie, H., Cui, G., Lin, D.,
& Li, Y.* (2024).
Monitoring norepinephrine release in vivo using next-generation GRABNE sensors.
Neuron. 112(12): 1930-1942. e6.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2023.06.22.546075
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· Deng, F.#, Wan, J.#, Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y., Liu, L., Yan, Y., Feng, J., Zhao, Y., Xie, H., & Li, Y.*(2024).
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo.
Nature Methods. 21(4): 692-702.
[Full Text]
[PDF]
[Supplemental Data]
[5-HT and Ca2+ Waves During Seizure]
[5-HT and eCB Waves During Seizure]
See also BioRxiv https://www.biorxiv.org/content/biorxiv/early/2023/05/30/2023.05.27.542566.full.pdf
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· Zhuo, Y.#, Luo, B.#, Yi, X., Dong, H.,
Miao, X., Wan, J., Williams, J. T., Campbell, M. G., Cai, R., Qian, T.,
Li, F., Weber, S. J., Wang, L., Li, B., Wei, Y., Li, G., Wang, H.,
Zheng, Y., Zhao, Y., Wolf, M. E., Zhu, Y., Watabe-Uchida, M., &
Li, Y.* (2024).
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.
Nature Methods. 21(4): 680-691.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.08.24.554559v1
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·
Wang, H.#, Qian, T.#, Zhao, Y., Zhuo, Y., Wu, C., Osakada, T.,
Chen, P., Chen, Z., Ren, H., Yan, Y., Geng, L., Fu, S.,
Mei, L., Li, G., Wu, L., Jiang, Y., Qian, W., Zhang, L., Peng, W., Xu, M., Hu, J.,
Jiang, M., Chen, L., Tang, C., Zhu, Y., Lin, D., Zhou, J.-N., & Li, Y.* (2023).
A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors.
Science , 382(6672), eabq8173.
[Full Text]
[PDF]
[Supplemental Data]
[Distinct SST Spatial Signal Patterns]
See also BioRxiv https://doi.org/10.1101/2022.03.26.485911
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· Wu, Z.#, Cui, Y.#, Wang, H.#, Wu, H., Wan, Y.,
Li, B., Wang, L., Pan, S., Peng, W., Dong, A., Yuan, Z., Jing, M.,
Xu, M., Luo, M.*, & Li, Y.* (2023).
Neuronal activity-induced, equilibrative nucleoside transporter-dependent,
somatodendritic adenosine release revealed by a GRAB sensor.
Proceedings of the National Academy of Sciences, 120(14), e2212387120.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.05.04.075564
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· Dong, H.#, Li, M.#, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R., & Li, Y.* (2023).
Genetically encoded sensors for measuring histamine release both in vitro and in vivo.
Neuron. 111(10): 1564-1576. e6.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.08.19.504485
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· Zeng, J.#*, Li, X.#, Zhang, R., Lv, M., Wang, Y., Tan, K., Xia, X., Wan, J., Jing, M., Zhang, X., Li, Y., Yang, Y., Wang, L., Chu, J., Li, Y., & Li, Y.*. (2023).
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.
Neuron. 111(7): 1118-1135. e5.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.03.27.485970
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· Qian, T.#, Wang, H.#, Wang, P.#, Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., & Li, Y.* (2023).
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.
Nature Biotechnology. 41(7): 944-957.
[Full Text]
[PDF]
[Supplemental Data]
[OT Signals in the VTA During Mating]
[OT Signals in the PVN During Mating]
[OT Signals in the PFC During Mating]
See also BioRxiv https://doi.org/10.1101/2022.02.10.480016
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· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T.,
Wang, H., Du, J., Jing, M., & Li, Y.* (2021). A sensitive GRAB sensor for detecting extracellular
ATP in vitro and in vivo Neuron, 110(5), 770-782.e775.
[Full Text]
[PDF]
[Supplemental Data]
[ATP and Microglia Dynamics in Zebrafish]
[ATP Release During Inflammation in Mice]
* Selected as the "Best of Neuron 2021-2022"
* See Comments Highlight by: Umpierre, A. D., Haruwaka, K., & Wu, L.-J.* (2022).
Getting a sense of ATP in real time.
Neuroscience Bulletin.
[Full Text]
[PDF]
See also BioRxiv https://doi.org/10.1101/2021.02.24.432680
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· Dong, A., He, K., Dudok, B., Farrell, J. S.,
Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Wang, H., Duan, J., Albarran, E.,
Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y.*. (2021).
A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo.
Nature Biotechnology. 40(5): 787-798.
[Full Text]
[PDF]
[Supplemental Data]
[eCB and Ca2+ Signals During Seizures]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.10.08.329169
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· Qian, C., Wu, Z., Sun, R., Yu, H., Zeng, J., Rao, Y., & Li, Y. *.
(2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife. 10: e65417.
https://doi.org/10.7554/eLife.65417.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2020.12.01.405605
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· Wan, J., Peng, W., Li, X., Qian, T.,
Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J.,
Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.
(2021). A genetically encoded sensor for measuring serotonin dynamics.
Nature Neuroscience. 24(5): 746-752. https://doi.org/10.1038/s41593-021-00823-7.
[Full Text]
[PDF]
[Supplemental Data]
[5-HT Release in Drosophila]
See also BioRxiv https://doi.org/10.1101/2020.02.24.962282
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· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020).
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods. 17(11), 1156-1166.
[Full Text]
[PDF]
[Supplemental Data]
[Mushroom Body DA Dynamics]
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· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J. , Trinh, S., Wu, R., Zhang, S., Pan, S., Hires, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020).
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, 17(11), 1139-1146.
[Full Text]
[PDF]
[Supplemental Data]
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· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*.
(2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.
[Full Text]
[PDF]
[Supplemental Data]
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· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.
[Full Text]
[PDF]
[Supplemental Data]
[Video Abstract]
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· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors.
Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.
[Full Text]
[PDF]
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· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366.
[Full Text]
[PDF]
[Supplemental Data]
* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS. eLife, 8, e45207.
[Full Text][PDF]
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· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J.,
Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z.,
Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G.
& Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and
specific detection of dopamine in flies, fish, and mice. Cell,
174(2), 481-496.
[Full Text]
[PDF]
[Supplemental Data]
[DA Signals Under Electrical Stimulation]
[DA Signals Under Odor Stimulation]
* See Viewpoint
by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New optical probes bring dopamine to light.
Biochemistry, 6379-6381. [Full Text][PDF> |
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· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*.
(2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737.
[Full Text]
[PDF][Supplemental Data]
[Supplemental Videos]
* See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648.
[Full Text]
[PDF]
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· Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053.
[Full Text]
[PDF]
[Supplemental Data]
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· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187.
[Full Text]
[PDF]
[Supplemental Data]
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Reviews, Book Chapters and Highlights
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· Dong, H., Wang, Z., & Li, Y.* (2025).
Genetically encoded dopamine sensors: principles, applications, and future directions.
Current Opinion in Behavioral Sciences. Volume 62, April 2025, 101489.
[Full Text]
[PDF]
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· Deng, F., Feng, J., Xie,H., & Li, Y.* (2025).
Mesoscopic Imaging of Neurotransmitters and Neuromodulators with Genetically Encoded Sensors.
Awake Behaving Mesoscopic Brain Imaging. Neuromethods, vol 214. Humana, New York.
[Full Text]
[PDF]
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· Wan, J., & Li, Y.* (2024).
STX-bpc: “Brightening” the path to neuronal inhibition.
Cell Chemical Biology. 31(7): 1233-1235.
[Full Text]
[PDF]
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· Yang, Y.#, Li, B.#, & Li, Y.* (2024).
Genetically Encoded Sensors for the In Vivo Detection of Neurochemical Dynamics.
Annual Review of Analytical Chemistry. 17.
[Full Text]
[PDF]
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· Zhao, Y., Wan, J., & Li, Y.* (2024).
Genetically encoded sensors for in vivo detection of neurochemicals relevant to depression.
Journal of Neurochemistry. 17.
[Full Text]
[PDF]
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· Zheng, Y., & Li, Y.* (2023).
Past, Present, and Future of Tools for Dopamine Detection.
Neuroscience, 525, 13-25.
[Full Text]
[PDF]
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· Qian, T., Wang, H., Xia, X., & Li, Y.* (2023)
Current and emerging methods for probing neuropeptide transmission.
Current Opinion in Neurobiology, 81, 102751.
[Full Text]
[PDF]
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· Dong, C.#, Zheng, Y.#, Long-Iyer, K., Wright, E. C., Li, Y.*, & Tian, L.* (2022).
Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors.
Annual Review of Neuroscience. 45(1): 273-294.
[Full Text]
[PDF]
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· Wu, Z., Lin, D., & Li, Y.* (2022).
Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.
Nature Reviews Neuroscience. 23(5): 257-274.
[Full Text]
[PDF]
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· Zhuo, Y., Li, Y.* (2022). New imaging methods for monitoring dopaminergic neurotransmission. Science China Life Sciences, 65.
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· Yulong Li. (2021). Neuron, 109(21), 3346-3348.
[Full Text]
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· Yu, H., Wangensteen, K., Deng, T., Li, Y., & Luo, W.* (2021). MRGPRX4 in Cholestatic Pruritus. Semin Liver Dis41(03), 358-367.
[Full Text]
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· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese)
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· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008.
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· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010.
[Full Text]
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· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]
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