Li Research Lab
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Selected publications


· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., ... *Luo, W. & *Li, Y.. (2019). MRGPRX4 is a novel bile acid receptor in cholestatic itch. bioRxiv. [Full Text] [PDF]

Research Articles

· Liang, X., Ho, M. C., Zhang, Y., Li, Y., Wu, M. N., Holy, T. E., & *Taghert, P. H. (2019). Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay. Neuron, 102(4), 843-857. [Full Text] [PDF]

· Feng, J., Zhang, C., Lischinsky, JE., Jing, M., ... & *Li, Y. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron, 102(4), 745-761. [Full Text] [PDF]

· #Wu, Z., #Feng, J., Jing, M., & *Li, Y. (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics. [Full Text] [PDF]

· #Zhou, M., #Chen, N., Tian, J., Zeng, J., ... Li, Y., *Guo, A., & *Li, Y. (2019). Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning. PNAS, 201812342. [Full Text] [PDF]

· Wu, L., Dong, A., Dong, L., Wang, S. Q., & *Li, Y. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366. [Full Text] [PDF]

→ See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS . eLife, 8, e45207. [Full Text] [PDF]

· #Li, B., #Wong, C., Gao, S. M., Zhang, R., Sun, R., Li, Y., & *Song, Y. (2018). The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. eLife, 7, e38181. [Full Text] [PDF]

· Tanaka, M., Sun, F., Li, Y., & *Mooney, R. (2018). A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. Nature, 563(7729), 117-120. [Full Text] [PDF][Extended data][Supplementary information]

· #Sun, F., #Zeng, J., #Jing, M., Zhou, J., Feng, J., Owen, S., ... & *Li, Y. (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496. [Full Text] [PDF][Suppl Video 1][Suppl Video 2]

→ See Viewpoint by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New Optical Probes Bring Dopamine to Light. Biochemistry, 6379-6381. [Full Text] [PDF]

· #Jing, M., #Zhang, P., Wang, G., Feng, J., Mesik, L., Zeng, J., ... *Zhu, JJ & *Li, Y. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737. [Full Text] [PDF][Suppl Figs][Suppl Videos]

→ See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648. [Full Text] [PDF]

· #Chen, B., #Huang, X., Gou, D., Zeng, J., ... & Li, Y., *Chen, L., *Wang, A. (2018). Rapid volumetric imaging with Bessel-Beam three-photon microscopy. Biomedical optics express, 9(4), 1992-2000. [Full Text] [PDF]

· Shen, Y., Ge, W. P., Li, Y., Hirano, A., Lee, H. Y., Rohlmann, A., ... *Fu, Y. H. & *Ptacek, L. J. (2015). Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences, 112(10), 2935-2941. [Full Text] [PDF]

· Liang, L., Li, Y., Potter, C. J., Yizhar, O., Deisseroth, K., Tsien, R. W., & *Luo, L. (2013). GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons. Neuron, 79(5), 917-931. [Full Text] [PDF]

·*Li, Y., & *Tsien, R. W. (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053. [Full Text] [PDF]

· Park, H., Li, Y., & *Tsien, R. W. (2012). Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science, 335(6074), 1362-1366. [Full Text] [PDF]

· *Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., ... & *Crabtree, G. R. (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature, 476(7359), 228-231. [Full Text] [PDF]

· Zhang, Q., Li, Y., & *Tsien, R. W. (2009). The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science, 323(5920), 1448-1453. [Full Text] [PDF]

· *Kuner, T., Li, Y., Gee, K. R., Bonewald, L. F., & Augustine, G. J. (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proceedings of the National Academy of Sciences, 105(1), 347-352. [Full Text] [PDF]

· Li, Y., Augustine, G. J., & *Weninger, K. (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187. [Full Text] [PDF]

Reviews, Book Reviews and Highlights

· *Dong, A., Liu, S., & *Li, Y. (2018). Gap Junctions in the Nervous System: Probing Functional Connections Using New Imaging Approaches. Frontiers in Cellular Neuroscience, 12, 320. [Full Text] [PDF]

· Wang, H., Jing, M., & *Li, Y. (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178. [Full Text] [PDF]

· #Wang, A., #Feng, J., *Li, Y., & *Zou, P. (2018). Beyond Fluorescent Proteins: Hybrid and Bioluminescent Indicators for Imaging Neural Activities. ACS chemical neuroscience, 9(4), 639-650. [Full Text] [PDF]

· Qian, C., & *Li, Y. (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929. [Full Text] [PDF]

· *Li, Y., & *Rao, Y. (2015). Pied Piper of Neuroscience. Cell, 163(2), 267-268. [Full Text] [PDF]